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Remarkable review on dedifferentiation, transdifferentiation and reprogramming
Today 21st January 2011 a remarkable review on dedifferentiation, transdifferentiation and reprogramming was published in Nature reviews Molecular Cell Biology. The authors describe the different routes of existing pathways of reprogramming that could eventually be used therapeutically in a not so distant future.
The core of our hypothesis "embryonic recall" describing "mechanotransduction" of venous vasculature as impulse to enter reprogramming cycles and pathways resemble some of the description published in this review. Our hypothesis describes the process of activation of coronary venous vasculature which may re-start pathways in an already injured myocardium salvaging cells, but also re-entering “embryonic” developmental processes. Further studies of our group are aiming to validate these processes in experimental studies and clinical trials. (embryonic_recall.pdf)
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
Chris Jopling, Stephanie Boue & Juan Carlos Izpisua Belmontep79 | doi:10.1038/nrm3043
http://www.nature.com/nrm/journal/v12/n2/full/nrm3043.html
Dedifferentiation, transdifferentiation and reprogramming could all be exploited to replace lost cells and tissues. Studies are aiming to understand the molecular details of these processes and to elucidate the advantages of one process over another for use in regenerative medicine.
A second interesting article was published recently on the periprocedural injury in elective PCI procedures, risk stratification for these patient as well as potential therapeutic options to prevent injury or its consequences. Although not mentioned in this article coronary sinus interventions might be a valuable tool in the prevention and will their application will be a focus in future reserach:
Review - Frontiers in cardiovascular medicine:
Girish Ganesha Babu, J. Malcolm Walker, Derek M. Yellon, and Derek J. Hausenloy
Peri-procedural myocardial injury during percutaneous coronary intervention: an important target for cardioprotection Eur Heart J (2011) 32(1): 23-31 doi:10.1093/eurheartj/ehq393